Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961). - Concepedia

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Deamination of glutamine is a prerequisite for optimal asparagine deamination by asparaginases in vivo (CCG-1961).

75

Citations

12

References

2004

Year

Eduard H. Panosyan, Rita Grigoryan, Ioannis A. Avramis, Nita L. Seibel, Paul S. Gaynon, Stuart E. Siegel, Howard Fingert, Vassilios I. Avramis

Abstract

Asparaginase activity of > or = 0.4 IU/ml provided optimal Asn and Gln deamination in high-risk ALL patients. Deamination of Gln correlates with enhanced serum Asn deamination in vivo. Therefore, deamination of Gln may enhance the antileukemic effect of ASNase.

References

	Year	Citations

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