Co‐inherited β‐thalassemia trait and HbH disease: clinical characteristics and interference in diagnosis of thalassemia by high‐performance liquid chromatography

Abstract

These cases, although relatively common in the South Chinese population, may be difficult do diagnose correctly when only examined on HPLC. Therefore, molecular analysis of the α and β globin genes should be done in all cases with hemolytic anemia and low MCV without clear HbH disease or β-thalassemia parameters.