THE INCIDENCE AND SIGNIFICANCE OF THE SICKLE CELL TRAIT

Abstract

Article1 December 1933THE INCIDENCE AND SIGNIFICANCE OF THE SICKLE CELL TRAITL. W. DIGGS, M.D., C. F. AHMANN, PH.D., JUANITA BIBB, A.B.L. W. DIGGS, M.D., C. F. AHMANN, PH.D., JUANITA BIBB, A.B.Author, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-7-6-769 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptIf one takes a drop of blood from each member of an unselected series of negroes, seals the drops under cover-slips, and examines them microscopically over a period of hours, he observes striking curved and pointed distortions of the erythrocytes in an appreciable number of the preparations. (Figure 1.) Erythrocytes assuming such bizarre stellate shapes are called "sickled cells" and individuals whose erythrocytes are capable of undergoing such a metamorphosis under suitable conditions are said to possess the "sickle cell trait." The anomaly is hereditary and is thought to be transmitted as a dominant Mendelian characteristic. Within the large group...Bibliography1. SYDENSTRICKERMULHERINHOUSEAL VPWARW: Sickle cell anemia, report of two cases in children, with necropsy in one case, Am. Jr. Dis. Child., 1923, xxvi, 132-156. CrossrefGoogle Scholar2. COOLEYLEE TBP: Sickle cell phenomenon, Am. Jr. Dis. Child., 1926, xxxii, 334-340. Google Scholar3. MIYAMOTOKORB KJH: Meniscocytosis (latent sickle cell anemia); its incidence in St. Louis, South. Med. Jr., 1927, xx, 912-916. CrossrefGoogle Scholar4. WOLLSTEINKREIDEL MKV: Sickle cell anemia, Am. Jr. Dis. Child., 1928, xxxvi, 998-1011. Google Scholar5. JOSEPHS H: Clinical aspects of sickle cell anemia, Bull. Johns Hopkins Hosp., 1928, xliii, 397-398. Google Scholar6. SMITH JH: Sickle cell anemia, Med. Clin. N. Am., 1928, xi, 1171-1190. Google Scholar7. DOLGOPOLSTITT VBRH: Sickle cell phenomenon in tuberculosis patients, Am. Rev. Tuberc., 1929, xix, 454-460. 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Author, Article, and Disclosure InformationAffiliations: Memphis, Tennessee*Received for publication March 31, 1933.From the Department of Clinical Pathology, University of Tennessee, Pathological Institute, Memphis, Tennessee, and from the Nutritional Division of the Experimental Station, University of Florida, Gainesville, Florida. 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II. Incidence and prevalence.HämoglobinopathienMenschliche H�moglobin-TypenMOLECULAR DISEASES OF HEMOGLOBIN. I. INTRODUCTION AND INCIDENCE*TOM P. HAYNIE, M.D., HAROLD L. DOBSON, M.D., ROBERT A. HETTIG, M.D.Pathologie des Hämoglobins und verwandter StoffeTHE GENETICS OF HUMAN HAEMOGLOBIN DIFFERENCES: PROBLEMS and PERSPECTIVESPaper: Sickle-cell anaemia and haemoglobin CAnomale menschliche H�moglobineNOTES ON SICKLE-CELL POLYMOKPHISM.Sickle-cell anemia complicating pregnancySickle-cell anemia complicated by pregnancySickle Cell Anemia and PregnancySickle cell anemia simulating poliomyelitis in a white adultRATIO OF SICKLE-CELL ANEMIA HEMOGLOBIN TO NORMAL HEMOGLOBIN IN SICKLEMICSSickle-cell disease and pregnancyLaboratory Diagnosis of Polycythemia and AnemiaSickle Cell Anemia, a Molecular DiseasePregnancy with sickle cell anemiaThe Inheritance of Sickle Cell AnemiaSickle cell anemia and pregnancyThe Anemic States: Their Causes and TreatmentSickle Cell Anemia and PregnancyThe incidence of sicklaemia in West AfricaPhysiology of ConvalescenceSickle-cell Trait and AnæmiaDie Erkrankungen des erythrocytären SystemsErbpathologie des Blutes und der blutbildenden OrganeErbpathologie des Blutes und der blutbildenden OrganeDie Sichelzellenanämie 1 December 1933Volume 7, Issue 6Page: 769-778KeywordsBlood cellsClinical pathologyNutrition ePublished: 1 December 2008 Issue Published: 1 December 1933 PDF downloadLoading ...