The influence of dietary fat and riboflavin on the formation of spontaneous hepatomas in the mouse.

Abstract

Fat enrichment of the diet from about 2 per cent to nearly 20 per cent appeared to enhance the rate of formation of the spontaneous hepatoma of the C3H mouse. Reduced dietary riboflavin, on the other hand, had no direct influence on the incidence of such hepatomas. These findings are discussed in relation to the effects of the two dietary modifications on the genesis of other tumors of the mouse and the azo dye-induced liver tumor of the rat.