Cisplatin otoprotection using transtympanic L‐N‐acetylcysteine: A pilot randomized study in head and neck cancer patients

Abstract

Although the study did not demonstrate a significant benefit overall, transtympanic L-NAC was associated with significantly better hearing in two patients. Better delivery methods may improve the efficacy of this treatment. L-NAC remains a promising drug in preventing cisplatin-induced ototoxicity.