Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients. - Concepedia

Concepedia

Publication | Open Access

Presence of a high amount of stroma and downregulation of SMAD4 predict for worse survival for stage I-II colon cancer patients.

DOI Full Paper Access

130

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0

References

2009

Year

Wilma E. Mesker, Gerrit‐Jan Liefers, Jan M. C. Junggeburt, Gabi W. van Pelt, Paola Alberici, Peter J.K. Kuppen, Noel F. de Miranda, Karin A. M. van Leeuwen, Hans Morreau, Károly Szuhai,

Abstract

Conventional haematoxylin-eosin stained tumor slides contain more prognostic information than previously fathomed. This can be unleashed by assessing the tumor-stroma ratio. The combination of analyzing the tumor-stroma ratio and staining for SMAD4 results in an independent parameter for confident prediction of clinical outcome.