Preferential activation of the vagal nodose nociceptive subtype by TRPA1 agonists in the guinea pig esophagus

Abstract

We conclude that the TRPA1 agonists are substantially more effective activators of the placodes-derived than the neural crest-derived esophageal nociceptors. Our data predict that in esophageal diseases the presence of endogenous TRPA1 activators will be preferentially signaled by the vagal nodose nociceptors.