Concepedia

Fasiglifam (TAK-875) Inhibits Hepatobiliary Transporters: A Possible Factor Contributing to Fasiglifam-Induced Liver Injury

Xiuli Li, Kan Zhong, Zitao Guo, Dafang Zhong, Xiaoyan Chen

Drug Metabolism and Disposition · 2015 · 84 citations · 33 references

DOI

Concepts

References

33

Drug export activity of the human canalicular multispecific organic anion transporter in polarized kidney MDCK cells expressing cMOAT (MRP2) cDNA.

Raymond Evers, Marcel Kool, Liesbeth van Deemter et al. · Journal of Clinical Investigation · 1998 · 615 citations · Full text

, , +17

Expression cloning of a rat liver Na(+)-independent organic anion transporter.

Emmanuel Jacquemin, Bruno Hagenbuch, Bruno Stieger et al. · Proceedings of the National Academy of Sciences · 1994 · 537 citations

, , +12

Hepatic Uptake of Bilirubin and Its Conjugates by the Human Organic Anion Transporter SLC21A6

Yunhai Cui, Jörg König, Inka Leier et al. · Journal of Biological Chemistry · 2001 · 516 citations · Full text

, , +14

The endothelin antagonist bosentan inhibits the canalicular bile salt export pump: A potential mechanism for hepatic adverse reactions

Karin Fattinger · Clinical Pharmacology & Therapeutics · 2001 · 505 citations · Full text

, , +17

The rat canalicular conjugate export pump (Mrp2) is down-regulated in intrahepatic and obstructive cholestasis

Michael Trauner, Marco Arrese, CJ Soroka et al. · Gastroenterology · 1997 · 499 citations

, , +17