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Sedative and Other Effects of Xylazine Given Intravenously to Horses
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1972
Year
Veterinary ResearchEducationPharmacotherapySummary XylazineXylazine Given IntravenouslyAtropine SulfateToxicologyClinical ChemistryAnesthetic PharmacologyAnimal PhysiologyVeterinary PhysiologyPharmacologyAnaesthetic AgentDepressed Heart RateAnimal SciencePhysiologyVeterinary ScienceAnesthesiaMedicineAnesthesiology
SUMMARY Xylazine (1.1 mg./kg.) given intravenously was a good sedative agent in the horse. Transient second-degree atrioventricular block (A-V) was induced by xylazine (0.55, 1.1, and 2.2 mg./kg.). This change was prevented by injection of 0.011 mg. or more of atropine sulfate per kilogram of body weight immediately before xylazine was given. Significant changes were not observed in respiratory rate or arterial blood gas values after xylazine or after atropine sulfate plus xylazine was given. Cardiovascular effects ( i.e ., depressed heart rate, blood pressure, and cardiac output) of xylazine were noticeable for at least 60 minutes after intravenous injection.