American Journal of Veterinary Research · 1972 · 97 citations · 0 references
Veterinary MedicinePharmacologyVeterinary PharmacologyAnesthesiaCardiovascular PharmacotherapyExperimental PharmacologyAnesthetic Drug PharmacologyCardiovascular Effects Of AnesthesiaCardiovascular MedicineCardiovascular PharmacodynamicsSedative PharmacologyVeterinary NeuropharmacologyAnesthetic Drug DosageBlood PressureCardiovascular Drug PharmacologyCardiovascular Effects Of SedativesHeart RateHemodynamic Drug EffectsRespiratory RateSecond-degree Atrioventricular Block
SUMMARY Xylazine (1.1 mg./kg.) given intravenously was a good sedative agent in the horse. Transient second-degree atrioventricular block (A-V) was induced by xylazine (0.55, 1.1, and 2.2 mg./kg.). This change was prevented by injection of 0.011 mg. or more of atropine sulfate per kilogram of body weight immediately before xylazine was given. Significant changes were not observed in respiratory rate or arterial blood gas values after xylazine or after atropine sulfate plus xylazine was given. Cardiovascular effects ( i.e ., depressed heart rate, blood pressure, and cardiac output) of xylazine were noticeable for at least 60 minutes after intravenous injection.