Targeting the<i>cis</i>‐dimerization of<scp>LINGO</scp>‐1 with low<scp>MW</scp>compounds affects its downstream signalling

Abstract

Our data suggest that LINGO-1 forms constitutive cis-dimers at the plasma membrane and that low MW compounds affecting the conformational state of these dimers can regulate LINGO-1 downstream signalling pathways. We propose that targeting the LINGO-1 dimerization interface opens a new pharmacological approach to the modulation of its function and provides a new strategy for drug discovery.