Activation and desensitization of <scp>TRPV1</scp> channels in sensory neurons by the PPARα agonist palmitoylethanolamide

Abstract

Activation of PPARα and TRPV1 channels, rather than of cannabinoid receptors, largely mediate PEA-induced [Ca²⁺](i) transients in sensory neurons. Differential TRPV1 activation and desensitization by CAP and PEA might contribute to their distinct pharmacological profile, possibly translating into potentially relevant clinical differences.