American Review of Respiratory Disease · 1987 · 144 citations · 9 references
Life SciencesPharmacologyPhysiologyEnvironmental PhysiologyExercise PhysiologySleep MedicineAltitude PhysiologyHypoxia PhysiologyRespiratory PathophysiologyRespiratory PharmacologyRespiratory PhysiologySleep PhysiologyArterial Oxygen SaturationHigh-altitude PhysiologyHypoxic Ventilatory ResponseOxygen SaturationPeriodic Breathing During SleepSleepSleep At AltitudeVentilatory Response To Hypoxia
We studied the effects of almitrine, acetazolamide, and placebo on the hypoxic ventilatory response (HVR), sleep periodic breathing, and arterial oxygen saturation (SaO2) in 4 healthy climbers. In a laboratory on Denali (Mt. McKinley) at 4,400 m (PB = 440 mm Hg), we used a double-blind, randomized, three-way crossover design. The HVR was measured during the waking state. Periodic breathing and SAO2% were measured during 3-h sleep studies. Almitrine and acetazolamide both increased SaO2% during sleep, although almitrine increased periodic breathing, whereas acetazolamide decreased periodic breathing. The HVR (delta VE/delta SaO2%) was doubled with almitrine (p less than 0.05), but unchanged with acetazolamide. The HVR was positively related to periodic breathing (p less than 0.05). We conclude that periodic breathing during sleep at high altitude is related to the hypoxic ventilatory response, and that acetazolamide is a superior agent to almitrine for ameliorating periodic breathing.
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Sleep physiology at high altitude
Martin Reite, Donald F. Jackson, Richard L. Cahoon et al. · Electroencephalography and Clinical Neurophysiology · 1975 · 187 citations
Sleep and Breathing at High Altitude
Himanshu Wickramasinghe, James D. Anholm · Sleep And Breathing · 1999 · 106 citations