Block and allosteric modulation of GABAergic currents by oenanthotoxin in rat cultured hippocampal neurons

Abstract

OETX shows a complex blocking mechanism of GABA(A) receptors, and the impact of this toxin is more potent on mIPSCs than on currents evoked by exogenous GABA. Such effects on GABAergic currents are compatible with the convulsions and epileptic-like activity reported for OETX.