PubMed · 1975 · 21 citations · 0 references
MedicineEndocrinologyGynecologyReproductive EndocrinologyReproductive MedicineReproductive PhysiologyHormonal ContraceptionHormonal InfluencesIntrauterine DevicesMenstrual CycleOvarian FunctionOvarian PhysiologyCorpus Luteum SteroidogenesisIntrauterine Contraceptive DevicesMenstrual Cycle BiomarkersMenstrual Cycle EndocrinologyMenstrual Cycle Hormone DynamicsProgesterone AssayProgesterone DynamicsProgesterone Measurement
Levels of progesterone, estradiol, LH, and FSH were measured in daily serum samples obtained from 4 subjects during a control cycle and during the first and fourth menstrual cycles after insertion of an intrauterine device (IUD). In addition, progesterone and estradiol were measured in serum samples obtained from 6 women 3, 4, or 5 months after IUD insertion, and from 6 women more than 1 year after IUD insertion. These measurements were compared to the data obtained from study of a large group of normal cycles. The results indicated that the IUD does not influence follicular maturation, time of ovulation, or corpus luteum function. The IUD did exert a local effect on the endometrium, causing the onset of menses to take place when steroid levels were higher than in control cycles.