PubMed · 1972 · 181 citations · 0 references
PharmacyNephrologyNuclear MedicineDrug ClearanceRenal Nuclear MedicineRenal PharmacokineticsGlomerular FiltrationRenal ClearanceRenal Drug ClearanceRenal Function TestingRenal Nuclear ImagingUrinary ExcretionGlomerular Filtration AssessmentGlomerular Filtration Rate AssessmentGlomerular Filtration Rate MeasurementGlomerular Filtration Rate TracersKidney Function MonitoringRapid Injection TechniqueRenal Clearance AssessmentRenal Filtration Fraction
Summary The usefulness of 99mTc-DTPA as an agent for measuring glomerular filtration rate was evaluated in five dogs and 11 human patients. In dogs, using a constant infusion technique, no change in 99mTc-DTPA clearance was found at different urine flow rates or following tubular blockade with probenecid. In the patients clearance of 99mTc-DTPA was 8% lower than that of 125I-iothalamate as determined by single-injection technique. The two compounds, however, had similar rates of plasma disappearance and urinary excretion. Thus 99mTc-DTPA, rapidly prepared by a kit method, is a useful addition to the list of radiopharmaceuticals that can be used for measurement of GFR.