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Evaluation of 99m Tc-DTPA for the measurement of glomerular filtration rate.
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1972
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99Mtc-dtpa ClearancePlasma DisappearanceGlomerulonephritisRenal FunctionBioanalysisClinical ChemistryChronic Kidney DiseaseLaboratory MedicineNuclear MedicineRadiologyHemodialysisKidney FailureConstant Infusion TechniqueGlomerular Filtration RateRenal PathophysiologyPharmacologyUrologyMedicineNephrologyKidney Research
Summary The usefulness of 99mTc-DTPA as an agent for measuring glomerular filtration rate was evaluated in five dogs and 11 human patients. In dogs, using a constant infusion technique, no change in 99mTc-DTPA clearance was found at different urine flow rates or following tubular blockade with probenecid. In the patients clearance of 99mTc-DTPA was 8% lower than that of 125I-iothalamate as determined by single-injection technique. The two compounds, however, had similar rates of plasma disappearance and urinary excretion. Thus 99mTc-DTPA, rapidly prepared by a kit method, is a useful addition to the list of radiopharmaceuticals that can be used for measurement of GFR.