Chromosome Aberrations Induced in Cultured Human Leucocytes by Herpes Simplex Virus Infection

Abstract

Human leucocytes in culture were infected with herpes simplex virus (HSV) with the multiplicity less than one and at about 10. Leucocytes exposed to a high viral inoculum showed chromosome aberrations, generally characterized by chromatidtype breaks.The most significant excess of breaks occurred in the middle segment of the long arms of chromosomes 6-X-12. Further, an excess of breaks was observed in the middle segment of the long arms of chromosomes 13-15 and chromosomes 4-5, and also in the middle and proximal segments of the long arm of chromosome 2.