Cognitive Performance Correlates with Cortical Isopeptide Immunoreactivity as Well as Alzheimer Type Pathology - Concepedia

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Cognitive Performance Correlates with Cortical Isopeptide Immunoreactivity as Well as Alzheimer Type Pathology

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2008

Year

Deng-Shun Wang, Hirotake Uchikado, David A. Bennett, Julie A. Schneider, Elliott J. Mufson, Joanne Wu, Dennis W. Dickson

Journal of Alzheimer s Disease

Abstract

Accumulation of insoluble proteins with isopeptide bonds correlates with cognitive impairment. The relationship of isopeptide to other proteins that are also enriched in formic acid extracts suggests that several substrates of tTG may play a role in the pathogenesis of AD.