Regulation of Fas receptor/Fas‐asssociated protein with death domain apoptotic complex and associated signalling systems by cannabinoid receptors in the mouse brain

Abstract

CB(1) receptors appear to exert a modest tonic activation of Fas/FADD complexes in brain. However, chronic CB(1) receptor stimulation decreased pro-apoptotic FADD and increased non-apoptotic p-FADD. The multifunctional protein FADD could participate in the mechanisms of neuroprotection induced by CBs.