The electrophysiological and mechanical effects of 2,3‐butane‐dione monoxime and cytochalasin‐D in the Langendorff perfused rabbit heart

Abstract

Extracellular [Ca2+] of 1.9 mmol l(-1) in conjunction with a moderate dose of Cyto-D (3 micromol l(-1)) reduced contractility with minimal effects on action potential duration and conduction at a fixed pacing cycle length. However, both BDM and Cyto-D had pronounced effects on electrical restitution.