PROGESTIN STUDIES: PREGNANDIOL EXCRETION¹²¹²

Abstract

THE EMPIRIC USE of numerous preparations of corpus luteum was enthusi′ astically, though fallaciously, practiced for years. Demonstration of an active principle, pr gestin, derived from the corpus luteum, has started a new era. At this time, it isdesirable to establish a factual basis for the new therapy, lest it also fall into disrepute. By what means can this be accom′ plishe¿ One would like to know the following: the normal secretion of progestin; the amount stored in the corpus luteum or other tissues; the amount in cir′ culation; its utili2ation,its excretion and physiologic action. The bioassay of corpora lutea to determine the amount of progestin present shows wide variation among different species of animals. In the human, the quantity of progestin stored in the corpus luteum is minimal. Large volumes of blood, even from pregnant women, do not contain enough for demonstration.