Importance of membrane‐bound catechol‐O‐methyltransferase in L‐DOPA metabolism: a pharmacokinetic study in two types of<i>Comt</i>gene modified mice

Abstract

In S-COMT-deficient mice, MB-COMT in the liver and the duodenum is able to O-methylate about one-half of exogenous L-DOPA. Sexual dimorphism and activity of the two COMT isoforms seems to be tissue specific and more prominent in peripheral tissues than in the brain.