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Single-radial-immunodiffusion potency tests of inactivated influenza vaccines for use in man and animals.
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1986
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VaccinationVaccinologyVeterinary VaccineAvian Influenza VaccinesVaccine DevelopmentPotency TestingVaccine ResearchImmunologyVaccine TestingVirologyInfluenza VaccineSingle-radial-immunodiffusion Potency TestsFlu VaccinationVaccine Ha ConcentrationMedicineInactivated Influenza VaccinesInfluenza Vaccines
Single-radial-immunodiffusion (SRD) provides a sensitive and reproducible in vitro assay for haemagglutinin (HA) concentration in inactivated influenza vaccines. The use of SRD for human influenza vaccine standardization and application for equine and avian influenza vaccines is discussed. In clinical trials, vaccine HA concentration measured by SRD has been shown to be directly related to antibody responses and to protection against challenge. The use of SRD may considerably reduce the usage of animals for potency testing of veterinary influenza vaccines.