The MEME Suite

TLDR

The MEME Suite is an integrated web-based platform for studying sequence motifs in proteins, DNA, and RNA, whose detection is crucial for understanding molecular interactions and gene regulation. Since its 2009 release, the MEME Suite has been expanded with six new tools. The suite’s capabilities are detailed with usage guidance and case studies that demonstrate how to combine its tools for effective motif‑based analyses. The MEME Suite is freely available for academic use at http://meme-suite.org, and its source code can be downloaded for local installation.

Abstract

The MEME Suite is a powerful, integrated set of web-based tools for studying sequence motifs in proteins, DNA and RNA. Such motifs encode many biological functions, and their detection and characterization is important in the study of molecular interactions in the cell, including the regulation of gene expression. Since the previous description of the MEME Suite in the 2009 Nucleic Acids Research Web Server Issue, we have added six new tools. Here we describe the capabilities of all the tools within the suite, give advice on their best use and provide several case studies to illustrate how to combine the results of various MEME Suite tools for successful motif-based analyses. The MEME Suite is freely available for academic use at http://meme-suite.org, and source code is also available for download and local installation.