Severe atypical neuropathy associated with administration of hematopoietic colony-stimulating factors and vincristine.

Abstract

Our results indicate that CSFs can precipitate SAN when given in conjunction with vincristine. The development of SAN was associated most strongly with the cumulative dose of vincristine -- the size of individual doses and the number of doses given in cycle 1 were important to the extent that they influenced the cumulative dose.