Role of oxidative stress in diabetic kidney disease.

Abstract

A comprehensive search of the literature was performed using MEDLINE and PubMed covering the period between 1966 and September 2009. The search for literature included only articles written in English. An article was rejected if it was clearly a letter or case report. The terms used for PubMed and Medline searches were: oxidative stress, reactive oxidant species, oxygen free radicals, diabetic nephropathy, and diabetic kidney disease. Formal inclusion and exclusion criteria were not defined for this review. The authors performed the analyses and statistical judgments in this review, and evaluated and identified articles for eligibility based on 4 criteria: 1) scientific relevance, 2) study design, 3) target population and 4) outcome.