Die Pharmazie · 2011 · 24 citations · 54 references
Veterinary MedicineImmunologyPharmacotherapyImmunopharmacologyInflammationInnate ImmunityHypersensitivity PharmacologyImmune Responses To InfectionInnate Immune ModulationProtozoan ImmunologyAntiprotozoal Drug TherapyAntiprotozoal PharmacologyGraft Versus Host Disease-associated InfectionsHost Immune Response ModulationImmune System InteractionsImmune System ModulationMetronidazole TherapyNitroimidazole Antiprotozoals
Metronidazole (MTZ) is a nitroimidazole antibiotic used mainly for the treatment of infections caused by susceptible organisms, particularly anaerobic bacteria and protozoa. Distinct from its antibiotic, amoebicidal, and antiprotozoal effects, MTZ displays immunopharmacological behaviour. This review outlines multiple effects of MTZ on different aspects of immunity, including innate and acquired immunity, and also highlights the immunopharmacological behaviour of MTZ in terms of its relevance to inflammation, delayed type hypersensitivity (DTH) and graft versus host disease (GVHD).
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