Life SciencesImmunologyPharmacologyImmunopharmacologyImmunoregulationInnate ImmunityCellular Immune ResponsesCytokine BiologyImmune Cell PhysiologyMacrophage BiologyNeutrophil BiologyPhagocyte BiologyGranulocyte ResponsesMacrophage ImmunomodulationNeutrophil Function Modulation
Tinospora cordifolia (Tc) is an Indian medicinal plant with proven immunomodulatory activity. This study was performed to elucidate its possible mechanism of action. We measured CFU-GM Cotony forming units of the granulocyte-macrophage series in serum of mice treated with Tc. We found that 10 days treatment with Tc (100 mg/ kg/d) induced a significant (p < 0.01) increase in the number of CFU-GM (255 +/- 49.32 vs 38.51 +/- 9.98) This suggests that activation of macrophages by Tc leads to increase in GM-CSF which leads to leucocytosis and improved neutrophil function.