Primaquine liposomes in the chemotherapy of experimental murine malaria

Abstract

Due to a significant reduction of toxicity, 100% curative (causal prophylactic) doses of primaquine diphosphate entrapped in liposomes (60 and 70 mg/kg body weight) can be administered in a single intravenous injection to treat sporozoite-induced Plasmodium berghei infections of mice.Although drug activity is not enhanced as compared to free drug, a simplified experimental therapy scheme could be developed, which may facilitate comparative pharmacokinetic studies of various drug delivery systems.