Beneficial role of Panax ginseng root aqueous extract against Cisplatin induced blood toxicity in rats

Abstract

Cisplatin is a water-soluble planar member of the platinum coordination complex class of anticancer drugs. The Current work aimed to study the effects of Ginseng extract against blood toxicity induced by Cisplatin in rats. A total 60 male albino rats were equally divided into six groups; the first and second groups were the control and ginseng groups respectively while the 3rd group was Cisplatin rat group; the 4th and 5th groups were Co- and post treated Cisplatin rat with ginseng respectively and the 6th group was Cisplatin self treated rat group. A significant increase in serum cholesterol, triglycerides, LDL, GPT, GOT, urea, creatinine, uric acids and MDA levels in Cisplatin group when compared with control group, in contrast, a significant decrease in HDl, calcium, potassium, albumin, GSH, catalase and total protein levels in Cisplatin group when compared with control group. Treatment of Cisplatin with ginseng improved the blood toxicity induced by Cisplatin. We can conclude that Co-treatment with ginseng has beneficial properties and can reduce the blood toxicity induced by Cisplatin.