Phytohemagglutinin-induced Lymphocyte Transformation: The Relationship to Prognosis of Hodgkin’s Disease

Abstract

Abstract Forty-three untreated patients with Hodgkin’s disease were evaluated between 1965 and 1967 with PHA-stimulated peripheral leukocyte cultures. No correlation was found between PHA-induced lymphocyte transformation at the time of diagnosis and the clinical course of the patient’s Hodgkin’s disease. There is also no correlation between lymphocyte transformation and the histologic pattern of nodular sclerosis. Although PHA-induced lymphocyte transformation appears to be a general index of immunologic status, it has not proven of value as a prognostic sign in Hodgkin’s disease.