Rare coding mutations identified by sequencing of <scp>A</scp>lzheimer disease genome‐wide association studies loci

Abstract

Targeted sequencing of confirmed GWAS loci revealed an excess burden of deleterious coding mutations in LOAD, with the greatest burden observed in ABCA7 and BIN1. Identifying coding variants in LOAD will facilitate the creation of tractable models for investigation of disease-related mechanisms and potential therapies.