Regional enhancement of cannabinoid CB₁ receptor desensitization in female adolescent rats following repeated Δ⁹‐tetrahydrocannabinol exposure

Abstract

These results suggest that the brains of adolescent females may be particularly vulnerable to disruption of CB(1) receptor signalling by marijuana abuse. Alternatively, increased desensitization may reflect protective adaptation. Given the extensive re-organization of the brain during adolescence, this disruption has potential long-term consequences for maturation of the endocannabinoid system.