Cell proliferation and cell cycle alterations in oesophageal <i>p53</i>‐mutated cancer cells treated with cisplatin in combination with photodynamic therapy

Abstract

Our results show that low CDDP doses (0.25-1 microm) induce cell mortality and cell cycle perturbation, which were more evident when given in combination with PDT, but in contrast to work of other authors no synergistic activity was found. Apoptosis occurred via intrinsic pathways in treated cells, although it did not represent the predominant mode of cell death.