Over‐expression of mitogen‐activated protein kinase phosphatase‐2 enhances adhesion molecule expression and protects against apoptosis in human endothelial cells

Abstract

Over-expression of MKP-2 had different effects upon the expression of inflammatory proteins due to a reciprocal effect upon JNK and NFκB signalling, and also prevented TNF-α-mediated endothelial cell death. These properties may make Adv.MKP-2 a potentially useful future therapy in cardiovascular diseases where endothelial dysfunction is a feature.