Role of acid and pepsin in acute experimental esophagitis.

Abstract

The roles of acid and pepsin in the production of acute feline esophagitis have been studied. Acid alone in high concentrations (pH 1.6 and 1.3) caused esophagitis. At lower acid concentration (pH 1.6 and 2.0), pepsin is an important factor in producing esophagitis. A suitable acid-pepsin solution has been selected for use as a standardized insult in an experimental model of esophagitis.