Liposome-Mediated Therapy of Intracranial Brain Tumors in a Rat Model

Multidrug-resistance gene (P-glycoprotein) is expressed by endothelial cells at blood-brain barrier sites.

Carlos Cordon‐Cardo, James P. O’Brien, D Casals et al. · Proceedings of the National Academy of Sciences · 1989 · 1.7K citations · Full text

Medicine, Oncology, Pharmacology +16

Sterically stabilized liposomes: improvements in pharmacokinetics and antitumor therapeutic efficacy.

Demetrios Papahadjopoulos, Theresa M. Allen, Alberto Gabizón et al. · Proceedings of the National Academy of Sciences · 1991 · 1.6K citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

Henry Brem, Steven Piantadosi, P. C. Burger et al. · The Lancet · 1995 · 1.4K citations · Full text

Pharmacy, Oncology, Surgery +16

Liposome formulations with prolonged circulation time in blood and enhanced uptake by tumors.

Alberto Gabizón, Demetrios Papahadjopoulos · Proceedings of the National Academy of Sciences · 1988 · 1.1K citations · Full text

Pharmacy, Pharmaceutics, Pharmacology +17

Microvascular permeability and interstitial penetration of sterically stabilized (stealth) liposomes in a human tumor xenograft.

Fan Yuan, Michael Leunig, S.K. Huang et al. · PubMed · 1994 · 912 citations

Pharmacy, Oncology, Pharmacokinetics +15