OSTI OAI (U.S. Department of Energy Office of Scientific and Technical Information) · 1972 · 287 citations · 0 references
Life SciencesPlant BiologyPlant SciencesBiogeochemistryPlant BiochemistryPlant PhysiologyCarbon AssimilationCarbon CycleCarbon FixationIsotope BiogeochemistryPlant RespirationStable Isotope AnalysisCarbon Isotopic FractionationIsotope FractionationStable Isotope Fractionation
We report the first isolation and characterization of the canine NKX2-5 gene. This canine homologue has high homology in genomic structure and functional domains to other NKX2-5 across a number of different species. Given the critical role of NKX2-5 in cardiac morphogenesis as seen in human and mouse studies of congenital heart defects, the availability of the canine NKX2-5 provides a good starting point for identifying mutations that may be responsible for certain forms of canine congenital heart defects.