The Journal of Immunology · 1969 · 172 citations · 0 references
Life SciencesImmunologyMicrobiologyHost-pathogen InteractionsInnate ImmunityMedical MicrobiologyAntibacterial AgentsBacterial ImmunologyBacterial InfectionsBacterial PathogenesisBacterial Virulence FactorsAntibacterial PeptidesBacterial Infection ImmunityPhagocyte Antimicrobial ActivityPhagocytosis EvasionPhagocytosis ModulationPhagocytosis Of BacteriaPhagocytosis ResistanceProtein-protein Association
Abstract Strains of Staphylococcus aureus possessing large amounts of protein A tended to resist phagocytosis more than strains that contain lesser amounts or none of this protein. Protein A extracted from S. aureus inhibited phagocytosis of both S. aureus and Escherichia coli in in vitro phagocytosis systems. The antiphagocytic effect was produced by nonspecific reaction of protein A with the Fc piece of γG globulin.