Induction of intestinal, mammary, and ovarian tumors in hamsters with oral administration of 20-methylcholanthrene.

Abstract

Summary Administration by stomach tube of 36–50 doses of 5 mg. of 20-methylcholanthrene to Syrian golden hamsters resulted in the occurrence of squamous-cell tumors of the forestomach, adenocarcinomas of the small and large intestine, adenocarcinomas of the mammary glands, thecomas of the ovaries, and sebaceous tumors of the skin and ear duct glands. Of these types of tumors, only a few squamous-cell papillomas of the forestomach were observed in control animals. Inflammatory lesions of the intestine with hyperplastic and atypical glands were a common finding in both experimental and control groups.