Mutation‐specific antibody detects mutant BRAF^V600E protein expression in human colon carcinomas

Abstract

A BRAF mutation-specific (V600E) antibody detected tumors with BRAFV600E mutations and exhibited complete concordance with a DNA-based method. These results support the use of IHC as a simplified strategy to screen colorectal cancers for BRAFV600E mutations in clinical practice.