CARCINOMA OF THE LUNG ASSOCIATED WITH MARKED ADRENOCORTICAL HYPERPLASIA AND ADRENAL HYPER-RESPONSIVENESS TO ACTH IN THE ABSENCE OF CUSHING'S SYNDROME

Abstract

Case Reports1 June 1961CARCINOMA OF THE LUNG ASSOCIATED WITH MARKED ADRENOCORTICAL HYPERPLASIA AND ADRENAL HYPER-RESPONSIVENESS TO ACTH IN THE ABSENCE OF CUSHING'S SYNDROMELEON J. MARKS, M.D., ALBERT E. ANDERSON, M.D., HARVEY LIBERMAN, M.D.LEON J. MARKS, M.D.Search for more papers by this author, ALBERT E. ANDERSON, M.D.Search for more papers by this author, HARVEY LIBERMAN, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-54-6-1243 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptThe role of pituitary corticotropin in the regulation of the adrenal secretion of cortisol during the basal state, as well as during periods of stress, has been well documented.1The work of several investigators has suggested the existence of a pituitary factor which is separate from conventional ACTH and which primarily affects adrenal growth and weight maintenance without causing the secretion of adrenal hormones.2, 3Although Jailer et al.4have demonstrated the presence of an adrenal weight-maintaining substance in patients with Cushing's disease due to bilateral adrenal hyperplasia by assaying their plasma in hypophysectomized rats, the clinical significance of a...Bibliography1. 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Young FG: ACTH—a single substance or a mixture of hormones. Adrenal Cortex, Transactions of the Fifth Conference, Josiah Macy, Jr. Foundation, 1954, p. 97. Google Scholar13. GoldbergLisser MBH: Acromegaly: a consideration of its course and treatment. J. Clin. Endocr. 2: 477, 1942. CrossrefGoogle Scholar14. LiddleIslandRinfretForsham GWDAPPH: Factors enhancing response of human adrenal to ACTH: is there an adrenal growth factor? J. Clin. Endocr. 14: 839, 1954. CrossrefGoogle Scholar This content is PDF only. To continue reading please click on the PDF icon. Author, Article, and Disclosure InformationAffiliations: Boston, Massachusetts*Received for publication June 8, 1960.From Steroid Research Laboratory and Department of Pathology, Boston Veterans Administration Hospital, Boston, Mass.Requests for reprints should be addressed to Leon J. Marks, M.D., Director, Steroid Research Laboratory, Veterans Administration Hospital, 150 S. Huntington Ave., Boston 30, Mass. 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GORMAN HILLS, M.D., KENNETH A. WOEBER, M.B., Ch.B. 1 June 1961Volume 54, Issue 6Page: 1243-1248KeywordsAdrenocorticotropic hormoneBlood plasmaCortisolLung and intrathoracic tumorsResearch laboratories ePublished: 1 December 2008 Issue Published: 1 June 1961 PDF downloadLoading ...