Loss of integrin αvβ6-mediated TGF-β activation causes Mmp12-dependent emphysema

A Mechanism for Regulating Pulmonary Inflammation and Fibrosis: The Integrin αvβ6 Binds and Activates Latent TGF β1

John S. Munger, Xiaozhu Huang, Hisaaki Kawakatsu et al. · Cell · 1999 · 2K citations

Inflammation, Fibrosis, Inflammatory Lung Disease +9

Requirement for Macrophage Elastase for Cigarette Smoke-Induced Emphysema in Mice

R. Dean Hautamaki, Dale K. Kobayashi, Robert M. Senior et al. · Science · 1997 · 1.5K citations

Inhibition of VEGF receptors causes lung cell apoptosis and emphysema

Yasunori Kasahara, Rubin M. Tuder, Laimute Taraseviciene‐Stewart et al. · Journal of Clinical Investigation · 2000 · 1.1K citations · Full text

Pathologic Changes in the Peripheral Airways of Young Cigarette Smokers

Dennis E. Niewoehner, Jerome Kleinerman, Donald B. Rice · New England Journal of Medicine · 1974 · 944 citations

Asthma, Tobacco Cessation, Pulmonary Care +23

Inducible targeting of IL-13 to the adult lung causes matrix metalloproteinase– and cathepsin-dependent emphysema

Tao Zheng, Zhou Zhu, Zhongde Wang et al. · Journal of Clinical Investigation · 2000 · 663 citations · Full text

Asthma, Inflammatory Lung Disease, Advanced Lung Disease +18