Concepedia

Estrogen provides neuroprotection against brain edema and blood brain barrier disruption through both estrogen receptors α and β following traumatic brain injury.

Vida Naderi-Boldaji, Mohammad Khaksari, Reza Abbasi, Fatemeh Maghool

PubMed · 2015 · 41 citations · 36 references

Abstract

A combined administration of MPP and PHTPP or ICI inhibited the E2-induced decrease in brain edema and BBB disruption; this may suggest that these effects were mediated via both receptors.

References

36

Induction of the Vitamin D Receptor Attenuates Autophagy Dysfunction-Mediated Cell Death Following Traumatic Brain Injury.

Changmeng Cui, Jianzhong Cui, Feng Jin et al. · PubMed · 2017 · 5.2K citations

Evaluation of an Estrogen Receptor-β Agonist in Animal Models of Human Disease

Heather A. Harris, Leo Albert, Yelena Leathurby et al. · Endocrinology · 2003 · 312 citations · Full text

, , +16

Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression

William R. Harrington, Shubin Sheng, Daniel Barnett et al. · Molecular and Cellular Endocrinology · 2003 · 302 citations

, , +11

Antagonists Selective for Estrogen Receptor α

Jun Sun, Ying Huang, William R. Harrington et al. · Endocrinology · 2002 · 232 citations · Full text

Estrogen Modulates Microglial Inflammatory Mediator Production via Interactions with Estrogen Receptor β

Ann Eldora Baker, Vielska M. Brautigam, Jyoti J. Watters · Endocrinology · 2004 · 227 citations · Full text

, , +17