Pathophysiologic Implications of Membrane Phospholipid Asymmetry in Blood Cells

Abstract

MANY STUDIES HAVE led to the concept that membrane phospholipid asymmetry is ubiquitous. In general terms, the outer leaflet of eukaryotic plasma membranes is formed predominantly with the cholinephospholipids (sphingomyelin and phosphatidylcholine [PC]), whereas the majority of the