Cytokines in tear fluid of patients with ocular graft-versus-host disease after allogeneic stem cell transplantation.

Abstract

IL-6 and IFN-γ were elevated in tear fluid of patients with ocular GvHD and correlated with different symptoms of dry eye disease, suggesting that IFN-γ is elevated during the early stages and IL-6 is involved in later stages of ocular GVHD and exhibits moreover an association with its severity.