MedicineOphthalmologyPharmacologyClinical PharmacologyOcular PharmacologyPharmacodynamicsOcular InflammationOcular PharmacodynamicsOphthalmic SuspensionsTopical Ocular Drug DeliveryTopical Ophthalmic MedicationsAnti-inflammatory Eye MedicationsAnti-inflammatory Ocular Drug EffectsArachidonic Acid SignalingIntraocular Pressure ElevationProstaglandin Biosynthesis InhibitorsProstaglandin InhibitorsProstaglandin Synthesis InhibitionTopical Anti-inflammatory Therapy
A comparative study was carried out of the inhibitory effect of 14 nonsteroidal anti-inflammatory compounds, administered topically, on the intraocular pressure and aqueous humor protein elevation induced by arachidonic acid in rabbits. The most effective agents were flurbiprofen solution and suspensions of indoxole (polysorbate-dispersed), meclofenamic acid, indomethacin, and clonixin.