Impact of <i>SLCO1B1</i> 521T &gt; C variant on leucovorin rescue and risk of relapse in childhood acute lymphoblastic leukemia treated with high‐dose methotrexate

Abstract

The SLCO1B1 c.521T > C variant was an important determinant of MTX disposition and their carriers were exposed to increased intensity and time of MTX. An appropriate leucovorin dose raise in variant group was beneficial to reducing the serious toxicity. The c.521T > C variant wasn't associated with the risk of ALL relapse.