Southern Medical Journal · 1985 · 10 citations · 0 references
Life SciencesInfectious DiseasesMicrobiologyAntimicrobial PharmacotherapyAntimicrobial ResistanceBacteriologyAntibacterial PharmacotherapyAntibacterial TherapyAntibiotic ResistanceBacterial InfectionsEmpiric Antimicrobial TherapyResistance In Gram-negative BacteriaBacterial Infection TreatmentBacterial Meningitis TreatmentMeningitis Antibiotic TherapyMeningitis Empiric TherapyMinimal Effective ConcentrationMultidrug-resistant Gram-negative Bacteria
A patient with meningitis caused by a strain of Actinetobacter anitratus that was resistant to all commercially available antibiotics was treated with imipenem/cilastatin administered intravenously in a dose of 1 gm of imipenem every six hours. The minimal inhibitory concentration of imipenem against the isolate was less than or equal to 0.04 micrograms/ml. The patient tolerated the drug well and was cured after 12 days of therapy.