The <scp>V</scp>al158<scp>M</scp>et polymorphism of the <i><scp>COMT</scp></i> gene is associated with increased pain sensitivity in morphine‐treated patients undergoing a painful procedure after cardiac surgery

Abstract

Our results show that the COMT Val158Met polymorphism contributes to variability in pain sensitivity after cardiac surgery of morphine-treated patients in the intensive care unit, because Met-allele carriers were more sensitive to overall pain and procedure-related pain.