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A circulating ligand for galectin-3 is a haptoglobin-related glycoprotein elevated in individuals with colon cancer1 1Investigators of the Great Lakes-New England Clinical and Epidemiology Center of the Early Detection Research Network are Dean Brenner, Daniel Normalle, and Kim Turgeon (University of Michigan), Sapna Syngal (Dana Farber Cancer Institute), Robert S. Bresalier (University of Texas M.D. Anderson Cancer Center), John Barron (Dartmouth/Hitchcock Medical Center), and Norman Marcon (University of Toronto).